β-tubulin (D3U1W) – 166Er

Catalog: 716601                                            Clone: D3U1W                                            Isotype: Mouse IgG2b
Reactivity: Human*, Mouse, Rat, Hamster, Monkey
Storage: Supplied in antibody stabilizer with 0.05% sodium azide. Store a 4°C

IHC: β-tubulin staining of  FFPE human tonsil

MIBI: β-tubulin staining (cyan) of FFPE human tonsil, counterstained with dsDNA (magenta)

IHC: β-tubulin staining of  FFPE human lung

MIBI: β-tubulin staining
(cyan) of FFPE human lung,  counterstained with dsDNA  (magenta)

Background: The cytoskeleton is composed of microfilaments, intermediate filaments, and microtubules.  β-tubulin, together with α-tubulin, forms heterodimers that serve as the building blocks for microtubules.  The structure of microtubules is dynamically regulated in processes related to cell movement, cytoplasmic transport, and chromosome alignment during meiosis/mitosis. β-tubulin is broadly expressed in eukaryotic cells. β-tubulin is the target of several anti-tubulin agents used in the treatment of cancer.

Validation: Each lot of conjugated antibody is quality control tested by MIBIscope™ analysis of stained tissue microarray using the appropriate positive and negative tissue field of views and are pathologist verified.

Recommended Usage: 1 uL per 100 uL staining volume using the MIBI™ Staining Protocol.
For optimal results, antibody should be titrated for each desired application.  Suggested starting range is 1:100.

References

  • Janke, C. The tubulin code: Molecular components, readout mechanisms, and functions. J Cell Biol. 2014; 206 (4)  461-472.

* Conjugate tested on human tissue.

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