CD163 Antibody – 142Nd

Catalog: 714201                                          Clone: EPR14643-36                                     Isotype: Rabbit IgG
Reactivity: Human*
Storage: CD163 antibody is supplied in antibody stabilizer with 0.05% sodium azide. Store at 4°C
IHC: CD163 antibody staining of  FFPE human tonsil
MIBI: CD163 antibody staining (cyan)  of FFPE human tonsil,  counterstained with   dsDNA (magenta)
IHC: CD163 antibody staining of  FFPE human liver
MIBI: CD163 antibody staining (cyan)  of FFPE human liver,  counterstained with   dsDNA (magenta)
Background: Expressed in monocytes and macrophages; used as a marker of M2 macrophages.  CD163 functions as an innate immune sensor for gram-positive and gram-negative bacteria. Anti-inflammatory activity has been associated with CD163 and higher expression of CD163 on tumor-associated macrophages has been reported to be associated with worse prognosis in several types of cancer.

Validation: Each lot of conjugated CD163 antibody is quality control tested by MIBIscope™ analysis of stained tissue microarray using the appropriate positive and negative tissue field of views and are pathologist verified.

Recommended Usage: 1 uL of CD163 antibody per 100 uL staining volume using the MIBI™ Staining Protocol.
For optimal results, antibody should be titrated for each desired application.  Suggested starting range is 1:100.

MIBI technology: Learn more about MIBI Technology, a multiplex IHC technology with unmatched sensitivity and true subcellular resolution.

References

  • Komohara Y, Jinushi M, Takeya M. Clinical significance of macrophage heterogeneity in human malignant tumors.  Cancer Science. 2014;105(1):1-8.

* Conjugate tested on human tissue.

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