CD163 (ERP14643-36) – 142Nd

Catalog: 714201                                          Clone: EPR14643-36                                     Isotype: Rabbit IgG
Reactivity: Human*
Storage: Supplied in antibody stabilizer with 0.05% sodium azide. Store a 4°C

IHC: CD163 staining of  FFPE human tonsil

MIBI: CD163 staining (cyan)  of FFPE human tonsil,  counterstained with   dsDNA (magenta)

IHC: CD163 staining of  FFPE human liver

MIBI: CD163 staining (cyan)  of FFPE human liver,  counterstained with   dsDNA (magenta)

Background: Expressed in monocytes and macrophages; used as a marker of M2 macrophages.  CD163 functions as an innate immune sensor for gram-positive and gram-negative bacteria. Anti-inflammatory activity has been associated with CD163 and higher expression of CD163 on tumor-associated macrophages has been reported to be associated with worse prognosis in several types of cancer.

Validation: Each lot of conjugated antibody is quality control tested by MIBIscope™ analysis of stained tissue microarray using the appropriate positive and negative tissue field of views and are pathologist verified.

Recommended Usage: 1 uL per 100 uL staining volume using the MIBI™ Staining Protocol.
For optimal results, antibody should be titrated for each desired application.  Suggested starting range is 1:100.

References

  • Komohara Y, Jinushi M, Takeya M. Clinical significance of macrophage heterogeneity in human malignant tumors.  Cancer Science. 2014;105(1):1-8.

* Conjugate tested on human tissue.

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