CD163 (ERP14643-36) – 142Nd
Catalog: 714201 Clone: EPR14643-36 Isotype: Rabbit IgG
Storage: Supplied in antibody stabilizer with 0.05% sodium azide. Store a 4°C
IHC: CD163 staining of FFPE human tonsil
MIBI: CD163 staining (cyan) of FFPE human tonsil, counterstained with dsDNA (magenta)
IHC: CD163 staining of FFPE human liver
MIBI: CD163 staining (cyan) of FFPE human liver, counterstained with dsDNA (magenta)
Background: Expressed in monocytes and macrophages; used as a marker of M2 macrophages. CD163 functions as an innate immune sensor for gram-positive and gram-negative bacteria. Anti-inflammatory activity has been associated with CD163 and higher expression of CD163 on tumor-associated macrophages has been reported to be associated with worse prognosis in several types of cancer.
Validation: Each lot of conjugated antibody is quality control tested by MIBIscope™ analysis of stained tissue microarray using the appropriate positive and negative tissue field of views and are pathologist verified.
Recommended Usage: 1 uL per 100 uL staining volume using the MIBI™ Staining Protocol.
For optimal results, antibody should be titrated for each desired application. Suggested starting range is 1:100.
- Komohara Y, Jinushi M, Takeya M. Clinical significance of macrophage heterogeneity in human malignant tumors. Cancer Science. 2014;105(1):1-8.
* Conjugate tested on human tissue.