CD21 Antibody – 170Er
Catalog: 717001 Clone: EP3093 Isotype: Rabbit IgG
Reactivity: Human*
Storage: CD21 antibody is supplied in antibody stabilizer with 0.05% sodium azide. Store a 4°C
IHC: CD21 staining of FFPE human tonsil
MIBI: CD21 staining (cyan) of FFPE human tonsil, costained with dsDNA (magenta)
IHC: CD21 staining of FFPE human follicular lymphoma
MIBI: CD21 staining (cyan) of FFPE human follicular lymphoma, costained with dsDNA (magenta)
Background: CD21 (complement C3d receptor (C3dR), complement receptor 2 (CR2), and Epstein-Barr virus receptor) is expressed on B cells, follicular dendritic cells, subsets of thymocytes and T cells, and pharyngeal epithelial cells. CD21 forms the B cell coreceptor complex with CD19 and CD81. EBV binds to CD21 and genetic variations in CD21 are associated with systemic lupus erythematosus.
Validation: Each lot of conjugated CD21 antibody is quality control tested by MIBIscope™ analysis of stained tissue microarrays using the appropriate positive and negative tissue field of views and are pathologist verified.
Recommended Usage: 1 uL of CD21 antibody per 100 uL staining volume using the MIBI™ Staining Protocol.
For optimal results, antibody should be titrated for each desired application. Suggested starting range is 1:100.
MIBI technology: Learn more about MIBI™ Technology, a multiplex IHC technology with unmatched sensitivity and true subcellular resolution.
References
- Roozendaal R., Carroll M.C. Complement receptors CD21 and CD35 in humoral immunity. Immunol Rev. 2007;219:157-66.
* Conjugate tested on human tissue.