CD68 (D4B9C) – 156Gd

Catalog: 715601                                            Clone: D4B9C                                          Isotype: Rabbit IgG
Reactivity: Human*
Storage: Supplied in antibody stabilizer with 0.05% sodium azide. Store a 4°C

IHC: CD68 staining of FFPE  human tonsil

MIBI: CD68 staining (cyan) of FFPE human tonsil,  counterstained with histone H3 (magenta)

IHC: CD68 staining of  FPE human liver

MIBI: CD68 staining (cyan)  of FFPE human liver,  counterstained with histone H3 (magenta)

Background: CD68  is a marker predominantly expressed on monocytes and macrophages and is used to identify tumor-associated macrophages (TAMs). Macrophages home to specific targets in part through the interaction between CD68 and tissue- and organ-specific lectins or selectins. CD68 staining can be combined with HLA-DR to identify M1 macrophages or with CD163 to identify M2 macrophages, macrophage phenotypes with prognostic associations to outcomes in certain cancers.

Validation: Each lot of conjugated antibody is quality control tested by MIBIscope™ analysis of stained tissue microarray using the appropriate positive and negative tissue field of views and are pathologist verified.

Recommended Usage: 1 uL per 100 uL staining volume using the MIBI™ Staining Protocol.
For optimal results, antibody should be titrated for each desired application.  Suggested starting range is 1:100.

References

  • Mei, J. et al. Prognostic impact of tumor-associated macrophage infiltration in non-small cell lung cancer: A systemic  review and meta-analysis. Oncotarget. 2016; 7(23): 34217-28.

* Conjugate tested on human tissue.

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