CD8 [CAL38] Antibody – 158Gd
Isotype: Rabbit IgG
IHC: CD8 staining of FFPE mouse ileum
MIBI: CD8 staining (cyan) of FFPE mouse ileum, costained with dsDNA (magenta)
Background: CD8 is a co-receptor for the T cell receptor (TCR) and is expressed on cytotoxic T cells. It is also expressed on cortical thymocytes, dendritic cells and NK cells. CD8 binds to MHC Class I to aid in antigen recognition and TCR-mediated activation. CD8 forms dimers of CD8ɑ and CD8β and clone CAL38 recognizes the alpha form of CD8.
Validation: Each lot of conjugated antibody is quality control tested by staining tissue following the MIBI Staining Protocol optimized for the applicable tissue format with subsequent MIBIscope analysis of stained tissue microarray using the appropriate positive and negative tissue field of views. These results are pathologist verified.
Recommended Usage: Mouse FFPE Tissue: 1:100 dilution.
For optimal results, the antibody should be titrated for each desired application.
MIBI technology: Learn more about MIBI™ Technology, a multiplex IHC technology with unmatched sensitivity and true subcellular resolution.
Guy, C. S. and Vignali, D. A. Organization of proximal signal initiation at the TCR:CD3 complex. Immunological Reviews. 2009; 232: 7-21.
* Conjugate tested on mouse tissue.