MIBI’s Groundbreaking Advances at ASMS 2024 Revolutionizes Complex Biology
Multiplexed Ion Beam Imaging (MIBI)’s groundbreaking advancements were proudly showcased at the American Society for Mass Spectrometry (ASMS) 2024 in three different posters and an oral presentation. These studies emphasize the power of MIBI in enhancing the understanding of complex biological systems, particularly in the context of spatial proteomics.
Executive summary
This collection of abstracts demonstrates the value of combining Multiplexed Ion Beam Imaging (MIBI) with Matrix-Assisted Laser Desorption Ionization (MALDI) by simultaneously extracting untargeted molecular composition and targeted single-cell phenotypes from the same sample, enabling comprehensive tissue analysis through multimodal imaging. This integration offers high-resolution insights into tumor microenvironments, revealing detailed immune-tumor interactions, identifying biomarkers, and facilitating personalized medicine. It also enhances the understanding of disease mechanisms, accelerates drug development, and optimizes combination therapies, ultimately leading to more effective and tailored treatment strategies.Integrating MIBI and Matrix-Assisted Laser Desorption Ionization (MALDI) for Comprehensive Tissue Analysis
A poster from scientists at Ionpath and Stanford School of Medicine introduced MnM, a groundbreaking workflow that integrates MALDI and MIBI imaging technologies for sequential analysis of the same tissue section. This innovative approach overcomes traditional platform limitations, allowing researchers to extract both untargeted molecular composition and targeted single-cell phenotypes from a single sample, setting a new standard for more precise and insightful comprehensive tissue analysis.
Cutting-Edge Glycomic Mapping Using MIBI to Understand Fast-Growing Brain Tumor
Another poster from Stanford researcher Mikaela Ribi (@MikaelaRibi, https://www.linkedin.com/in/mikaela-ribi-b59017142/), in collaboration with scientists from Stanford and University of South Carolina, illustrated results on High-Grade Gliomas (HGG), a fast-growing brain tumor, using the combined power of dual imaging modalities to map the spatial distribution of N-glycans and identify crucial interactions within glioma tissues. By doing so, scientists gained a deeper understanding of glioma progression from low to high-grade lesions, shedding light on the biochemical diversity driving glioma severity and recurrence.
MIBI’s High-Resolution Insights in Bone Marrow Analysis
In the last poster presented at ASMS 2024, researchers from Stanford University and the Medical University of South Carolina also utilized MnM to provide comprehensive insights into the cellular composition and spatial organization of the bone marrow, enhancing our understanding of complex biological systems and disease mechanisms. The study highlighted the enhanced ability to analyze complex biological systems, paving the way for better understanding of cellular interactions and disease mechanisms.
MIBI Unveils the Role of Glycosylation in Maternal-Fetal Interface Invasion
In an oral presentation, a Stanford University scientist highlighted the critical role of glycosylation at the maternal-fetal interface during early pregnancy. By analyzing decidua samples with the use of MIBI, they discovered new insights into the role of N-glycans in healthy pregnancies and complications such as pre-eclampsia and intrauterine growth restriction.
Looking Ahead
The advancements presented at ASMS 2024 reaffirm Ionpath’s commitment to pushing the boundaries of spatial proteomics with MIBI technology. As we continue to innovate, our focus remains on providing researchers with powerful tools to unravel the complexities of biological systems, ultimately contributing to breakthroughs in disease understanding and treatment.
For more detailed information on our ASMS 2024 presentation and to stay updated with our latest research, follow us on LinkedIn and visit our website.