Spatial Proteomic Services
TISSUE PROFILING SERVICES THAT DELIVER ACTIONABLE INSIGHTS FOR BIOPHARMA
Leverage our expertise for unparalleled actionable information for your tissue imaging and analysis needs
Let Ionpath’s expert team help you gain actionable insights from your tissue samples with MIBI-enabled high-definition spatial proteomic services
Our Spatial Proteomic Services provides custom tissue imaging and analysis of your samples with unprecedented insight—enabling pharmaceutical and biotechnology companies to accelerate discovery and development.
By leveraging our proprietary MIBI-enabled™ multiplexed imaging platform and our multi-disciplinary team of expert scientists, we can help you gain key insights for developing the next generation of immunotherapies and targeted therapies.
Deep, quantitative analysis of the tissue microenvironment by our expert team
- Identification and enumeration of cell populations
- Quantification of protein expression at the single-cell level
- Analysis of spatial interactions with unmatched depth
Try our Spatial Proteomics Pilot Program!
Interested in finding out how MIBI technology will work for your samples?
Let Ionpath’s expert team help you gain unparalleled actionable insights from your tissue samples with MIBI-enabled tissue profiling services.
PROGRAM FEATURES
- Immune profiling with our antibody panel
- Analysis of up to 10 slides
- Classification of 26 cell populations plus checkpoint expression
- Spatial analysis of including nearest neighbor and tumor-immune boundary
Expert data analysis to transform images into insight
Expert analysis of the tumor microenvironment with the most advanced imaging technology and data science available
We then transform that information into actionable insights using robust statistical methods and machine learning to help uncover mechanism of action and identify responder populations.
Achieve your objectives with our streamlined approach
We help you at every step—from design to image acquisition to analysis
Projects defined in collaboration with our Expert Team
Our expert team of immunologists, pathologists and data scientists will work with you to define a project plan, including a bespoke staining panel and custom analyses, to meet your experimental objectives.
STAINING
MIBI is compatible with all common sample types including fresh-frozen and FFPE tissue
Start with one of our pre-validated panels and customize it with additional markers of your choosing. We have pre-validated panels for both human and mouse tissue. If you have an antibody that works by conventional IHC, we’ll likely be able to validate it for MIBI.
IMAGING
All imaging is done with the proprietary MIBIscope™ system
We can image ten slides or hundreds of samples, and all imaging is overseen by a pathologist ensuring consistency throughout data acquisition.
ANALYSIS
Images are analyzed by our data science team to yield insights into the tumor microenvironment
Standard analyses include comprehensive enumeration of immune cell populations, quantification of checkpoint marker expression on a single-cell basis, and spatial profiling. For example, we can quantify the proximity of effector cells, such as PD-1+, CD8+ T cells, to target cells, such as proliferating PD-L1+ tumor cells, and generate a host of similar statistics in order to differentiate responders from non-responders.
All data can be made available through MIBItracker, our interactive, cloud-based data visualization tool.
Leverage our multi-disciplinary scientific team to accelerate your research
Detailed communication, close collaboration, and disciplined project management ensure successful progress and on-time completion of objectives.
Our expert team is comprised of scientists with deep experience in pathology, immuno-oncology, and bioinformatics. Our scientists have published in top-tier, peer-reviewed journals and conducted research at leading institutions.
Our in-house scientists will collaborate closely with you and manage assay development, reagent validation, tissue staining, imaging and scanning. Then our bioinformatics team will analyze the data and provide you with spatial information and quantitative single-cell analysis. You’ll have fully analyzed data at your fingertips and complete access to our internal experts, so you can get to the next steps in your project faster.
Quality & Reproducibility
Quality is at the core of our process
Consistent data quality is maintained across large cohort studies with multiple layers of controls. All antibody validation is conducted across a variety of tissue types and according to the standards of the College of American Pathology.
“I bring the same quality standards to Ionpath that I employed as a medical director in clinical practice.”