Arginase-1 (EPR6672(B)) – 150Nd

Catalog: 715001                                            Clone: EPR6672(B)                                          Isotype: Rabbit IgG
Reactivity: Human*
Storage: Supplied in antibody stabilizer with 0.05% sodium azide. Store a 4°C

IHC: Arginase-1 staining of  FFPE human liver

MIBI: Arginase-1 staining  (cyan) of FFPE human liver,  counterstained with Histone H3 (magenta)

IHC: Arginase-1 staining of  FFPE human thymus

MIBI: Arginase-1 staining
(cyan) of FFPE human  thymus, counterstained with  Histone H3 (magenta)

Background: Arginase-1 is expressed by liver cells, myeloid-derived suppressor cells (MDSCs), macrophages, and neutrophils.  In mammals, there are three enzymes that metabolise arginine: two arginase isoforms  (ARG1, ARG2) and inducible nitric oxide synthase (iNOS). Arginase-1 catalyzes the breakdown of L-arginine into L-ornithine and urea as the final step in the urea cycle.  L-arginine is a  necessary metabolite for T cell receptor signaling and T cell proliferation. Arginase is induced by inflammation. In cancer, MDSCs within the tumor microenvironment (TME) produce arginase-1 resulting in low levels of available L-arginine within the TME leading to attenuated T cell responsiveness.

Validation: Each lot of conjugated antibody is quality control tested by MIBIscope™ analysis of stained tissue microarray using the appropriate positive and negative tissue field of views and are pathologist verified.

Recommended Usage: 1 uL per 100 uL staining volume using the MIBI™ Staining Protocol.
For optimal results, antibody should be titrated for each desired application.  Suggested starting range is 1:100.


  • Rodríguez, P.C., Ochoa A.C. Arginine regulation by myeloid derived suppressor cells and tolerance in cancer:  mechanisms and therapeutic perspectives. Immunol Rev. 2008; 222:180-91.
  • McGaha T.L. et al. Amino acid catabolism: a pivotal regulator of innate and adaptive immunity. Immunol Rev. 2012;  249(1):135-57.

* Conjugate tested on human tissue.

Contact Us

We are glad that you prefer to contact us. Please fill our short form and one of our friendly team members will contact you back.

Immuno-oncology/CancerNeuroscienceInfectious DiseaseImmunologyStem CellOther

Contact Us

We are using cookies on our website

Please confirm, if you accept our tracking cookies. You can also decline the tracking, so you can continue to visit our website without any data sent to third party services.