MIBIscope™ System

TRANSFORMING MULTIPLEXED TISSUE IMAGING

  • Visualize 40+ markers in a single scan

  • Comprehensively phenotype immune infiltrate

  • Quantify protein expression

  • Profile tissue architecture

A revolutionary technology for analysis of the tumor microenvironment

The MIBIscope™ System is a revolutionary imaging platform, enabling comprehensive phenotypic profiling and spatial analysis of the tissue microenvironment. The MIBIscope allows researchers to visualize over 40 markers simultaneously with higher sensitivity, resolution, and throughput than existing methods.

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Visualize 40+ Markers in a Single Image

The MIBIscope enables over 40 markers to be visualized simultaneously with single step staining and single step imaging.

MIBIscope images from a 3mm x 3mm scan of a granulomatous lung section from a Mycoplasm tuberculosis infected patient. The image to the left shows immune infiltrate in the infected tissue (CD45, yellow; CD31, red; SMA, blue; CD68, magenta). Zoomed in single-channel images shown to the right.

High Throughput

Image up to 90 800x800 µm2 ROIs per day

The MIBIscope can be automated to run 24/7, allowing researchers to conduct studies on large clinical cohorts and image hundreds of samples a week.

High Resolution

Achieve confocal resolution

The MIBIscope can be adjusted like an optical microscope with resolution settings from 280 nm to 1 µm. At higher magnifications the MIBIscope provides comparable resolution to confocal microscopy.

Data adapted from Keren et al., Science Advances, 2019.

High Sensitivity

Single molecule sensitivity

The MIBIscope uses highly sensitive Secondary Ion Mass Spectrometry, allowing for single molecule detection. A recent study in Science Advances demonstrated the extraordinary sensitivity of the MIBIscope system.

Data adapted from Keren et al., Science Advances, 2019.

SPECIFICATIONS

Available Biomarker Channels40
Resolution280 nm – 1 µm
ROI Size200x200 – 800x800 µm2
Acquisition Time (per 800x800 µm2)
Coarse Resolution (1 µm)
16 min
Fine Resolution (650 nm)
68 min
Super-fine Resolution (450 nm)
4.5 hrs
Lower Limit of Detection (number of Ab)1 (113In) – 16 (166Er)
Dynamic Range5 log
File TypeTIFF
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Immuno-oncology/CancerNeuroscienceInfectious DiseaseImmunologyStem CellOther


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