CD11c Antibody – 144ND

Catalog: 714401                                            Clone: EP1347YB                                          Reactivity: Human*
<span”>Storage: CD11c antibody is supplied in antibody stabilizer with 0.05% sodium azide. Store a 4°C

IHC: CD11c antibody staining of FFPE human tonsil

MIBI: CD11c antibody staining (cyan) of FFPE tonsil,  counterstained with dsDNA (magenta)

IHC: CD11c antibody staining of FFPE human lung

MIBI: CD11c antibody staining (cyan) of FFPE human lung, counterstained with
dsDNA (magenta)

Background: CD11c is expressed by dendritic cells, monocytes, macrophages, neutrophils, and some B cells. CD11c is one of four β2 integrins along with CD11a, C11b and CD11d. CD11c is a receptor for fibrinogen and functions in chemotaxis and cell adhesion. Integrins mediate myeloid cell recruitment from the blood vessels into tissue and lymph nodes and contribute to the immunological synapse between T cells and antigen presenting cells.

Validation: Each lot of conjugated CD11c antibody is quality control tested by MIBIscope™ analysis of stained tissue microarray using the appropriate positive and negative tissue field of views and are pathologist verified.

Recommended Usage: 1 uL of CD11c antibody per 100 uL staining volume using the MIBI™ Staining Protocol.
For optimal results, antibody should be titrated for each desired application.  Suggested starting range is 1:100.

MIBI technology: Learn more about MIBI Technology, a multiplex IHC technology with unmatched sensitivity and true subcellular resolution.

References

  • Schittenhelm, L., Hilkens, C.M., and Morrison, V.L. β2 Integrins As Regulators of Dendritic Cell, Monocyte, and
    Macrophage Function. Front Immunol. 2017; 20(8):1866.

* Conjugate tested on human tissue.

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