CD11c (EP1347Y) – 144ND

Catalog: 714401                                            Clone: EP1347YB                                          Isotype: Rabbit IgG
Reactivity: Human*
Storage: Supplied in antibody stabilizer with 0.05% sodium azide. Store a 4°C

IHC: CD11c staining of FFPE human tonsil

MIBI: CD11c staining (cyan) of FFPE tonsil,  ounterstained with dsDNA (magenta)

IHC: CD11c staining of FFPE human lung

MIBI: CD11c staining (cyan) of FFPE human lung, counterstained with
dsDNA (magenta)

Background: CD11c is expressed by dendritic cells, monocytes, macrophages, neutrophils, and some B cells. CD11c is one of four β2 integrins along with CD11a, C11b and CD11d. CD11c is a receptor for fibrinogen and functions in chemotaxis and cell adhesion. Integrins mediate myeloid cell recruitment from the blood vessels into tissue and lymph nodes and contribute to the immunological synapse between T cells and antigen presenting cells.

Validation: Each lot of conjugated antibody is quality control tested by MIBIscope™ analysis of stained tissue microarray using the appropriate positive and negative tissue field of views and are pathologist verified.

Recommended Usage: 1 uL per 100 uL staining volume using the MIBI™ Staining Protocol.
For optimal results, antibody should be titrated for each desired application.  Suggested starting range is 1:100.

References

  • Schittenhelm, L., Hilkens, C.M., and Morrison, V.L. β2 Integrins As Regulators of Dendritic Cell, Monocyte, and
    Macrophage Function. Front Immunol. 2017; 20(8):1866.

* Conjugate tested on human tissue.

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