CD20 Antibody – 167Er

Catalog: 716701                                        Clone: L26                                             Isotype: Mouse IgG2a
Reactivity: Human*
Storage: CD20 antibody is supplied in antibody stabilizer with 0.05% sodium azide. Store a 4°C

IHC: CD20 staining of FFPE human tonsil

MIBI: CD20 staining (cyan) of FFPE human tonsil, costained with dsDNA (magenta)

IHC: CD20 staining of FFPE human thymus

MIBI: CD20 staining (cyan) of FFPE human thymus, costained with dsDNA (magenta)

Background: CD20 is an activated-glycosylated phosphoprotein expressed on B cells from late pro-B cells through memory B cells but is absent from plasma cells. CD20 is involved in the transport of calcium and calcium-dependent intracellular signaling pathways. Anti-CD20 therapy is used to treat diseases with a B cell component such as B-cell chronic lymphocytic leukemia (B-CLL) and rheumatoid arthritis (RA).

Validation: Each lot of conjugated CD20 antibody is quality control tested by MIBIscope™ analysis of stained tissue microarrays using the appropriate positive and negative tissue field of views and are pathologist verified.

Recommended Usage: 1 uL of CD20 antibody per 100 uL staining volume using the MIBI™ Staining Protocol.
For optimal results, antibody should be titrated for each desired application.  Suggested starting range is 1:100.

MIBI technology: Learn more about MIBI Technology, a multiplex IHC technology with unmatched sensitivity and true subcellular resolution.

References

  • Walport M, Murphy K, Janeway C, Travers PJ (2008). Janeway’s Immunobiology (7th ed.). New York: Garland Science.
  • Payandeh, Z., Bahrami, A. A., Hoseinpoor, R., Mortazavi, Y., Rajabibazl, M., Rahimpour, A., Taromchi, A. H., Khalil, S. The applications of anti-CD20 antibodies to treat various B cells disorders. Biomedicine & Pharmacotherapy. 2019; 109:2415-2426.

* Conjugate tested on human tissue.

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