CD206 [E6T5J] Antibody – 174Yb
Catalog: 717404
Clone: E6T5J
Isotype: Rabbit IgG
Reactivity: Human, Mouse*, Rat, Monkey
Application: MIBI-FFPE
Storage: Supplied in antibody stabilizer with 0.05% sodium azide. Store at 4°C
IHC: CD206 antibody staining of FFPE mouse liver
MIBI: CD206 staining (cyan) of FFPE mouse liver, costained with dsDNA (magenta)
IHC: CD206 antibody staining of FFPE mouse CT26 tumor
MIBI: CD206 staining (cyan) of FFPE mouse CT26 tumor, costained with dsDNA (magenta)
Background: The mannose receptor CD206 is predominantly expressed on the surface of macrophages, dendritic cells and liver sinusoidal endothelial cells. CD206 mediates endocytosis and phagocytosis as well as activation of macrophages and antigen presentation and, therefore, plays an important role in host defense. Expression of CD206 on tumor-associated macrophages has been associated with immunosuppression, tumorigenesis and resistance to cancer therapies.
Validation: Each lot of conjugated antibody is quality control tested by staining tissue following the MIBI Staining Protocol optimized for the applicable tissue format with subsequent MIBIscope analysis using the appropriate positive and negative tissue field of views. These results are pathologist verified.
Recommended Usage: Mouse FFPE: 1:100 dilution.
For optimal results, the antibody should be titrated for each desired application.
MIBI technology: Learn more about MIBI™ Technology, a multiplex IHC technology with unmatched sensitivity and true subcellular resolution.
References
Pablo Scodeller et al. Precision targeting of tumor macrophages with a CD206 binding peptide. Sci Rep. 2017 Nov 7;7(1):14655.
* Conjugate tested on mouse tissue.