CD31 [D8V9E] Antibody – 152Sm

Catalog: 715202 
Clone: D8V9E
Isotype: Rabbit IgG
Reactivity: Mouse*
Application: MIBI-FFPE
Storage: Supplied in antibody stabilizer with 0.05% sodium azide. Store at 4°C

IHC: CD31 staining of FFPE mouse liver
MIBI: CD31 staining (cyan) of FFPE mouse liver, costained with dsDNA (magenta)
IHC: CD31 staining of FFPE mouse ileum
MIBI: CD31 staining (cyan) of FFPE mouse ileum, costained with dsDNA (magenta)

Background: CD31, also known as platelet endothelial cell adhesion molecule-1 (PECAM-1), plays roles in leukocyte transmigration, angiogenesis, and integrin activation. Specifically, CD31 is highly expressed at endothelial cell-cell junctions, functioning as an adhesion protein to maintain endothelial cell junctional integrity and restore the vascular permeability barrier following inflammatory or thrombotic challenge. The expression of CD31 on endothelial cells makes it a useful marker of the vasculature within the tumor. CD31 can also be found on platelets, monocytes, and granulocytes.

Validation: Each lot of conjugated antibody is quality control tested by staining tissue following the MIBI Staining Protocol optimized for the applicable tissue format with subsequent MIBIscope analysis of stained tissue microarray using the appropriate positive and negative tissue field of views. These results are pathologist verified.

Recommended Usage: Mouse FFPE Tissue: 1:100 dilution.
For optimal results, the antibody should be titrated for each desired application.

MIBI technology: Learn more about MIBI Technology, a multiplex IHC technology with unmatched sensitivity and true subcellular resolution.

Lertkiatmongkol P., Liao D., Mei H., Hu Y., Newman P.J. Endothelial functions of platelet/endothelial cell adhesion molecule-1 (CD31). Curr Opin Hematol. 2016; 23(3):253-9.

* Conjugate tested on mouse FFPE tissue.

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