IDO1 Antibody – 171Yb

Catalog: 717101                                        Clone: EPR20374                                         Isotype: Rabbit IgG
Reactivity: Human*
Storage: IDO1 antibody is supplied in antibody stabilizer with 0.05% sodium azide. Store at 4°C
IHC: IDO1 staining of FFPE human tonsil
MIBI: IDO1 staining (cyan) of FFPE human tonsil, costained with dsDNA (magenta)
IHC: IDO1 staining of FFPE human lung adenocarcinoma
MIBI: IDO1 staining (cyan) of FFPE human lung adenocarcinoma, costained with dsDNA (magenta)
Background: IDO1 (indolamine 2,3-dioxygenase) catalyzes the conversion of the essential amino acid tryptophan to N-formylkynurenine.  IDO1 is expressed by suppressive macrophages and in some tumor cells. IDO1 is induced by interferon gamma. The reduction of tryptophan in the tumor microenvironment and the production of kynurenine inhibit T cell responses and contribute to a suppressed immune state. Inhibition of IDO1 is an area of active research in cancer immunotherapy, particularly in combination with other therapies.

Validation: Each lot of conjugated IDO1 antibody is quality control tested by MIBIscope™ analysis of stained tissue microarrays using the appropriate positive and negative tissue field of views and are pathologist verified.

Recommended Usage: 1 uL of IDO1 antibody per 100 uL staining volume using the MIBI™ Staining Protocol.
For optimal results, antibody should be titrated for each desired application.  Suggested starting range is 1:100.

MIBI technology: Learn more about MIBI Technology, a multiplex IHC technology with unmatched sensitivity and true subcellular resolution.

References

  • Zhai, L., Ladomersky, E., Lenzen, A., Nguyen, B., Patel, R., Lauing, K.L,, Wu, M., Wainwright, D.A. IDO1 in cancer: a Gemini of immune checkpoints. Cellular & Molecular Immunology. 2018; 15:447–457.

* Conjugate tested on human tissue.

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