Na/K-ATPase [EP1845Y] Antibody – 176Yb

Catalog: 717603 
Clone: EP1845Y
Isotype: Rabbit IgG
Reactivity: Human*, Mouse*, Rat, and Tilapia
Application: MIBI-FFPE
Storage: Supplied in antibody stabilizer with 0.05% sodium azide. Store at 4°C

IHC: Na/K-ATPase staining of FFPE mouse pancreas
MIBI: Na/K-ATPase staining (cyan) of FFPE mouse pancreas, counterstained with dsDNA (magenta)
IHC: Na/K-ATPase staining of FFPE human liver
MIBI: Na/K-ATPase staining (cyan) of FFPE human liver, counterstained with dsDNA (magenta)
Background: Na/K-ATPase is a widely expressed membrane protein that functions as an ion pore, exporting sodium and importing potassium. The alpha, beta and FXYD subunits combine to form Na/K-ATPase. The regulation of intracellular concentrations of various ions control signaling pathways and other enzymatic processes, such as neurotransmitter reuptake in astrocytes. Na/K-ATPase activity is regulated through multiple phosphorylation sites. Mutations in the alpha subunit of Na/K-ATPase in particular have been shown to adversely impact ionic homeostasis, contributing to neurological disease.

Validation: Each lot of conjugated antibody is quality control tested by staining tissue following the MIBI Staining Protocol optimized for the applicable tissue format with subsequent MIBIscope analysis using the appropriate positive and negative tissue field of views. These results are pathologist verified.

Recommended Usage: Human and Mouse FFPE tissue: 1:100 dilution.
For optimal results, the antibody should be titrated for each desired application.

MIBI technology: Learn more about MIBI Technology, a multiplex IHC technology with unmatched sensitivity and true subcellular resolution.

Clausen, M.V., Hilbers, F. and Poulsen H. (2017) The Structure and Function of the Na,K-ATPase Isoforms in Health and Disease. Front. Physiol. 8:371. doi: 10.3389/fphys.2017.00371

* Conjugate tested on FFPE human and mouse tissues.

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