PD-L1 Antibody – 149Sm
Isotype: Rabbit IgG
IHC: PD-L1 antibody staining of FFPE human diffuse large B cell lymphoma
MIBI: PD-L1 antibody staining (cyan) of FFPE human diffuse large B cell lymphoma, costained with dsDNA (magenta)
IHC: PD-L1 antibody staining of FFPE human thymic SCC
MIBI: PD-L1 antibody staining (cyan) of FFPE human thymic SCC, costained with dsDNA (magenta)
Background: Programmed cell death 1 ligand 1 (PD-L1, CD274) binds to PD-1 and inhibits T cell activation.
Validation: Each lot of conjugated antibody is quality control tested by staining tissue following the MIBI Staining Protocol optimized for the applicable tissue format with subsequent MIBIscope analysis using the appropriate positive and negative tissue field of views. These results are pathologist verified.
Recommended Usage: Human FFPE: 1:100 dilution. For optimal results, the antibody should be titrated for each desired application.
MIBI technology: Learn more about MIBI™ Technology, a multiplex IHC technology with unmatched sensitivity and true subcellular resolution.
- Wimberly, H. et al. PD-L1 Expression Correlates with Tumor-Infiltrating Lymphocytes and Response to Neoadjuvant Chemotherapy in Breast Cancer. Cancer Immunol Res. 2015; 3(4): 326-332.
- Bindels, S. et al. Regulation of PD-L1 by SIP1 in human epithelial breast tumor cells. Oncogene. 2006; 25:4975–4985.
* Conjugate tested on human tissue.