CD45 Antibody – 175Lu
Catalog: 717504 Clone: D9M8I Isotype: Rabbit IgG
Reactivity: Human*, Monkey Application: MIBI-FFPE
Storage: CD45 antibody is supplied in antibody stabilizer with 0.05% sodium azide. Store at 4°C
IHC: CD45 staining of FFPE human tonsil
IHC: CD45 antibody staining of FFPE human lymphoma
MIBI: CD45 staining (cyan) of FFPE human lymphoma, counterstained with dsDNA (magenta)
Background: CD45, also known as the leukocyte common antigen, is a type I transmembrane protein and a member of the protein tyrosine phosphatase expressed on all hematopoietic cells except mature erythrocytes, platelets and plasma cells. CD45 isoforms show cell-type and differentiation-stage specific expression, a pattern which is quite well conserved in mammals. These isoforms are often used as markers that identify and distinguish between different types of immune cells.
Validation: Each lot of conjugated antibody is quality control tested by staining tissue following the MIBI Staining Protocol optimized for the applicable tissue format with subsequent MIBIscope analysis using the appropriate positive and negative tissue field of views.
Recommended Usage:Human FFPE: 2 ug/mL dilution. For optimal results, the antibody should be titrated for each desired application.
References
- Leupin O., Zaru R., Laroche T., Müller S., Valitutti S.Exclusion of CD45 from the T-cell receptor signaling area in antigen-stimulated T lymphocytes. Curr Biol. 2000;10(5):277-80.
* Conjugate tested on human tissue.