Podoplanin Antibody – 170Er

Catalog: 717002                                        Clone: D2-40                                         Isotype: Mouse IgG1
Reactivity: Human*
Storage: Podoplanin antibody is supplied in antibody stabilizer with 0.05% sodium azide. Store a 4°C

IHC: Podoplanin staining of FFPE human tonsil

MIBI: Podoplanin staining (cyan) of FFPE human tonsil, costained with dsDNA (magenta)

IHC: Podoplanin staining of FFPE human lung squamous cell carcinoma

MIBI: Podoplanin staining (cyan) of FFPE human lung squamous cell carcinoma, costained with dsDNA (magenta)

Background: Podoplanin is a mucin-type membrane protein expressed on the endothelium of lymphatic vessels, lung alveolar cells, and kidney podocytes. Podoplanin is also expressed in tumor cells, such as squamous cell carcinomas, and in cancer-associated fibroblasts (CAFs). High levels of podoplanin are associated with an increased incidence of metastasis to lymph nodes and decreased survival time of patients.

Validation: Each lot of conjugated Podoplanin antibody is quality control tested by MIBIscope™ analysis of stained tissue microarrays using the appropriate positive and negative tissue field of views and are pathologist verified.

Recommended Usage: 1 uL of Podoplanin antibody per 100 uL staining volume using the MIBI™ Staining Protocol.
For optimal results, antibody should be titrated for each desired application.  Suggested starting range is 1:100.

MIBI technology: Learn more about MIBI Technology, a multiplex IHC technology with unmatched sensitivity and true subcellular resolution.

References

  • Ugorski, M., Dziegiel, P., Suchanski, J. Podoplanin – a small glycoprotein with many faces. Am J Cancer Res. 2016; 6(2):370-86.

* Conjugate tested on human tissue.

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